Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives

crafthouse by fortessa glass smoking box with handheld smoker Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine and 2-chloro-4-vinylquinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2-chloro-4-(2-substituted ethyl)quinazolines.Treatment of these products, without isolation, with N-methylpiperazine results in nucleophilic displacement of chloride mars landing kale and yields the corresponding 2,4-disubstituted pyrimidines and quinazolines.